Thermostable exoshells fold and stabilize recombinant proteins
نویسندگان
چکیده
منابع مشابه
Thermostable tag (TST) protein expression system: engineering thermotolerant recombinant proteins and vaccines.
Methods to increase temperature stability of vaccines and adjuvants are needed to reduce dependence on cold chain storage. We report herein creation and application of pVEX expression vectors to improve vaccine and adjuvant manufacture and thermostability. Defined media fermentation yields of 6g/L thermostable toll-like receptor 5 agonist flagellin were obtained using an IPTG inducible pVEX-fla...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2017
ISSN: 2041-1723
DOI: 10.1038/s41467-017-01585-2